Gold-Catalyzed Formal Cycloaddition of 2-Ethynylbenzyl Ethers with Organic Oxides and α-Diazoesters


  • We thank the National Science Council, Taiwan for financial support of this research.


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A world of possibilities: Gold-catalyzed reactions of 2-ethynylbenzyl ethers with organic oxides and α-diazoesters gave 1,3-dihydroisobenzofuran and naphthalene derivatives, respectively (see scheme; EWG=electron-withdrawing group). Mechanisms for the formation of the formal cycloadducts were elucidated by isotope labeling.