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Keywords:

  • configuration determination;
  • cytotoxicity;
  • lipids;
  • natural products;
  • NMR spectroscopy
Thumbnail image of graphical abstract

From Antarctic waters: Human anaplastic thyroid carcinoma (ATC) cells which stably express antisense construct against nuclear high-mobility group A (HMGA) proteins were used in a novel phenotypic assay for screening marine natural extracts. The rational search led to the isolation and identification of a novel polyoxygenated linear lipid (1) that showed important and selective cytotoxicity against ATC-derived tumor cell lines.