Mycalol: A Natural Lipid with Promising Cytotoxic Properties against Human Anaplastic Thyroid Carcinoma Cells

Authors

  • Dr. Adele Cutignano,

    1. Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Napoli (Italy) http://www.icb.cnr.it
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  • Dr. Genoveffa Nuzzo,

    1. Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Napoli (Italy) http://www.icb.cnr.it
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  • Dr. Daniela D'Angelo,

    1. Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Via Pansini 5, 80131, Napoli (Italy)
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  • Dr. Eleonora Borbone,

    1. Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Via Pansini 5, 80131, Napoli (Italy)
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  • Dr. Alfredo Fusco,

    Corresponding author
    1. Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Via Pansini 5, 80131, Napoli (Italy)
    • Alfredo Fusco, Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Via Pansini 5, 80131, Napoli (Italy)

      Angelo Fontana, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Napoli (Italy) http://www.icb.cnr.it

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  • Dr. Angelo Fontana

    Corresponding author
    1. Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Napoli (Italy) http://www.icb.cnr.it
    • Alfredo Fusco, Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Via Pansini 5, 80131, Napoli (Italy)

      Angelo Fontana, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Napoli (Italy) http://www.icb.cnr.it

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  • We are deeply grateful to Ernesto Mollo for taxonomic identification of the sponge. Carmine Iodice, Dominique Melck, and Maurizio Zampa are also acknowledged for recording CD, NMR, and HR-MS spectra, respectively. This work was supported by Italian PNRA, Project SMART funded by Regione Campania (2009.0932025) and Associazione Italiana per la Ricerca sul Cancro (AIRC) and the Ministero dell’Università e della Ricerca Scientifica e Tecnologica MIUR (PRIN 2008). D.D’A. is recipient of a fellowship from Fondazione Italiana per la Ricerca sul Cancro (FIRC).

Abstract

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From Antarctic waters: Human anaplastic thyroid carcinoma (ATC) cells which stably express antisense construct against nuclear high-mobility group A (HMGA) proteins were used in a novel phenotypic assay for screening marine natural extracts. The rational search led to the isolation and identification of a novel polyoxygenated linear lipid (1) that showed important and selective cytotoxicity against ATC-derived tumor cell lines.

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