Inside Cover: Synthesis and Application of β-Substituted Pauson–Khand Adducts: Trifluoromethyl as a Removable Steering Group (Angew. Chem. Int. Ed. 20/2013)

Authors

  • Nuria Aiguabella,

    1. Institute for Research in Biomedicine (IRB Barcelona), Baldiri i Reixac, 10, 08028 Barcelona (Spain)
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  • Dr. Carlos del Pozo,

    1. Dept. de Química Orgánica, Universidad de Valencia, 46100 Burjassot (Spain)
    2. Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe, 46012 Valencia (Spain)
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  • Prof. Xavier Verdaguer,

    1. Institute for Research in Biomedicine (IRB Barcelona), Baldiri i Reixac, 10, 08028 Barcelona (Spain)
    2. Dept. de Química Orgànica, Universitat de Barcelona, Martí i Franqués, 1, 08028 Barcelona (Spain)
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  • Prof. Santos Fustero,

    1. Dept. de Química Orgánica, Universidad de Valencia, 46100 Burjassot (Spain)
    2. Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe, 46012 Valencia (Spain)
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  • Prof. Antoni Riera

    Corresponding author
    1. Institute for Research in Biomedicine (IRB Barcelona), Baldiri i Reixac, 10, 08028 Barcelona (Spain)
    2. Dept. de Química Orgànica, Universitat de Barcelona, Martí i Franqués, 1, 08028 Barcelona (Spain)
    • Institute for Research in Biomedicine (IRB Barcelona), Baldiri i Reixac, 10, 08028 Barcelona (Spain)
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Abstract

original image

Full steam ahead to β-substituted Pauson–Khand adducts: By using the trifluoromethyl group as a removable steering group, A. Riera and co-workers synthesized the previously unknown regioisomers of the Pauson–Khand reaction of terminal alkynes, as they describe in their Communication on page 5355 ff The synthetic potential of the new adducts has been shown by a short formal synthesis of α-cuparenone (artwork by Pau Martin Malpartida from a picture of Leo Reynolds).

Cartoon 1.

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