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Keywords:

  • asymmetric catalysis;
  • atom economy;
  • cooperative catalysis;
  • ketimines;
  • synthetic methods
Thumbnail image of graphical abstract

A cooperative catalyst consisting of a soft Lewis acid and a hard Brønsted base promoted the title reaction. The N-thiophosphinoyl group on the ketimines was critical to surpass the high activation barrier through the soft–soft interaction of sulfur and copper. Mannich adducts with a tetrasubstituted stereogenic center were produced with excellent diastereo- and enantioselectivities. TANIAPHOS= ferrocenyl ligand.