Templated Hierarchical Self-Assembly of Poly(p-aryltriazole) Foldamers


  • This work was supported by the South African Research Chairs Initiative (SARChI) from the Department of Science and Technology (DST), the National Research Foundation (NRF), the Council for the Chemical Sciences of the Netherlands Organisation for Scientific Research, and the EU (ITN Hierarchy, contract PITN-2007-215851). R.P. thanks the Marie Curie Fellowship for financial support. We thank Rinske Knoop for the TEM and cryoTEM images, and Franscious Cummings for the TEM images.


original image

A biomimetic approach has been used for the templated self-assembly of a helical poly(para-aryltriazole) foldamer. The solvophobic folding process yields helices that further self-assemble into long nanotubes (see picture; scale bar: 100 nm). Constructs of controlled length and chirality can be generated by applying a poly(γ-benzyl-l-glutamate) scaffold at the appropriate assembly conditions, mimicking tobacco mosaic virus self-assembly.