Odorless Isocyanide Chemistry: An Integrated Microfluidic System for a Multistep Reaction Sequence


  • This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government(MEST) (2008-0061983).


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Can't smell this: An integrated continuous-flow microfluidic setup enables in situ generation, extraction, separation, and reaction of foul-smelling isocyanides with little exposure to the surroundings. Isocyanides were generated by dehydration of the corresponding N-substituted formamides, and several representative isocyanide-based organic reactions were successfully performed. DIPEA=N,N-diisopropylethylamine.