Cover Picture: A Facile Strategy for Selective Incorporation of Phosphoserine into Histones (Angew. Chem. Int. Ed. 22/2013)

Authors

  • Sangsik Lee,

    1. Department of Chemistry, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)
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  • Seunghee Oh,

    1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)
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  • Aerin Yang,

    1. Department of Chemistry, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)
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  • Jihyo Kim,

    1. Department of Chemistry, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)
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  • Prof. Dieter Söll,

    1. Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Ave, New Haven, CT 06511 (USA)
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  • Prof. Daeyoup Lee,

    Corresponding author
    1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)
    • Daeyoup Lee, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)

      Hee-Sung Park, Department of Chemistry, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)

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  • Prof. Hee-Sung Park

    Corresponding author
    1. Department of Chemistry, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)
    • Daeyoup Lee, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)

      Hee-Sung Park, Department of Chemistry, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701 (Republic of Korea)

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Abstract

original image

Selective phosphoserine incorporation is described by H.-S. Park et al. in their Communication on page 5771 ff. A general strategy for producing recombinant histones with site-specific serine phosphorylation has been developed by engineering phosphoseryl-tRNA synthethase (SepRS) and elongation factor Tu (EF-Tu). This method should facilitate the study of histone phosphorylation and cross-regulatory mechanisms.

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