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Keywords:

  • phosphoserine;
  • unnatural amino acids;
  • histones;
  • phosphorylation;
  • protein engineering
Thumbnail image of graphical abstract

Selective phosphoserine incorporation is described by H.-S. Park et al. in their Communication on page 5771 ff. A general strategy for producing recombinant histones with site-specific serine phosphorylation has been developed by engineering phosphoseryl-tRNA synthethase (SepRS) and elongation factor Tu (EF-Tu). This method should facilitate the study of histone phosphorylation and cross-regulatory mechanisms.