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Keywords:

  • asymmetric synthesis;
  • 5,6-dihydroindolizines;
  • iminium–enolate compounds;
  • organocascade reactions
Thumbnail image of graphical abstract

Indolizine skeletons: A highly efficient dual iminium–enolate generation/activation process is introduced as a new platform for the design of organocatalytic intermolecular domino reactions for the direct construction of 5,6-dihydroindolizine derivatives. This process provides ready access to indolizine skeletons with high optically purity from simple starting materials (see picture).