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Addressing Challenges in Palladium-Catalyzed Cross-Couplings of Aryl Mesylates: Monoarylation of Ketones and Primary Alkyl Amines

Authors


  • We are grateful to the NSERC of Canada, the Killam Trusts, and Dalhousie University for their generous support of this work. Dr. Michael Lumsden (NMR-3, Dalhousie) is thanked for assistance in the acquisition of NMR spectroscopic data and Mr. Xiao Feng (Maritime Mass Spectrometry Laboratories, Dalhousie) is thanked for assistance in the acquisition of spectrometric data.

Abstract

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Mor(DalPhos) for Me(sylates): Described are the first examples of ketone mono-α-arylation and primary aliphatic amine monoarylation employing aryl methanesulfonate coupling partners. A range of functionalized aryl mesylates were employed with dialkyl ketones, and also with primary and secondary amines as well as the otherwise challenging coupling partners acetone and methylamine. Ad=adamantyl.

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