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Total Synthesis of Indotertine A and Drimentines A, F, and G

Authors

  • Yu Sun,

    1. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
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    • These authors contributed equally to this work.

  • Ruofan Li,

    1. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
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    • These authors contributed equally to this work.

  • Wenhao Zhang,

    1. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
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  • Prof. Dr. Ang Li

    Corresponding author
    1. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)
    • State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China)

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  • We thank Dr. D. J. Edmonds for helpful discussions. Financial support was provided by Ministry of Science and Technology (2013CB836900), the National Natural Science Foundation of China (21290180, 21172235, and 21222202), and Chinese Academy of Sciences.

Abstract

original image

Oh my darling, Drimentine: The first total synthesis of the pyrroloindoline alkaloids drimentines A, F, and G, and their congener, indotertine A, is reported. An intermolecular radical conjugate addition was key in the synthesis of the drimentine alkaloids, and a biologically inspired iminium–olefin cyclization converted drimentine F into indotertine A.

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