This research was supported in part by a Grant-in-Aid for Young Scientists (B) from MEXT (No. 23750116) and by Project Funding for Basic Science from RIKEN.
Trifluoromethylation Reactions for the Synthesis of β-Trifluoromethylamines†
Article first published online: 13 JUN 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 30, pages 7841–7844, July 22, 2013
How to Cite
Egami, H., Kawamura, S., Miyazaki, A. and Sodeoka, M. (2013), Trifluoromethylation Reactions for the Synthesis of β-Trifluoromethylamines . Angew. Chem. Int. Ed., 52: 7841–7844. doi: 10.1002/anie.201303350
- Issue published online: 17 JUL 2013
- Article first published online: 13 JUN 2013
- Manuscript Received: 20 APR 2013
- MEXT. Grant Number: 23750116
- multicomponent reactions;
A multitalented system: N-Migratory oxytrifluoromethylation and one-pot three-component reactions of allylamines as well as the aminotrifluoromethylation of alkenyl amines all proceeded efficiently in the presence of the Togni reagent (1) and CuI to afford a variety of β-trifluoromethylamine derivatives (see scheme).