Inside View of a Giant Proton Pump

Authors

  • Prof. Dr. Ulrich Brandt

    Corresponding author
    1. Exzellenzcluster “Macromolecular Complexes”, Goethe-Universität, Frankfurt am Main (Germany)
    2. Nijmegen Center for Mitochondrial Disorders, Radboud University Nijmegen Medical Center, Geert Groteplein-Zuid 10, 6525 GA Nijmegen (The Netherlands)
    • Exzellenzcluster “Macromolecular Complexes”, Goethe-Universität, Frankfurt am Main (Germany)
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Abstract

original image

Inner workings: The X-ray crystal structure of the entire bacterial complex I at 3.3 Å resolution offers fascinating insights into a giant 536 kDa molecular machine. The respiratory chain complex seems to employ unique mechanisms of energetic coupling that are entirely different from those found in all other enzymes using redox energy to drive vectorial proton transport across a bioenergetic membrane.

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