In Situ Generation of Diimide from Hydrazine and Oxygen: Continuous-Flow Transfer Hydrogenation of Olefins


  • This work was supported by a grant from the Christian Doppler Research Society (CDG). We gratefully thank Prof. Walter Goessler for performing ICP-MS measurements. S.T.N. thanks CNPq for a fellowship. D.C. thanks the Research, Technological Innovation, and Supercomputing Center of Extremadura (CénitS) for their support in the use of LUSITANIA computer resources.


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No catalyst required! A highly efficient, catalyst-free process to generate diimide in situ from hydrazine monohydrate and molecular oxygen for the selective reduction of alkenes has been developed. The use of a gas–liquid segmented flow system allowed safe operating conditions and dramatically enhanced this atom-economical reaction, resulting in short processing times.