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Hydrogen Bonding and Alcohol Effects in Asymmetric Hypervalent Iodine Catalysis: Enantioselective Oxidative Dearomatization of Phenols


  • Financial support for this project was partially provided by JSPS.KAKENHI (24245020, 22750087), the Program for Leading Graduate Schools: IGER Program in Green Natural Sciences (MEXT), and JSPS Research Fellowships for Young Scientists (T.Y.). We thank Niiha Sasakura for HRMS analysis.


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Iodine chooses: A conformationally flexible C2-symmetric organoiodine(III) catalyst for the highly enantioselective catalytic oxidative dearomatization of phenols has been developed. Catalysis is controlled by intramolecular hydrogen-bonding interactions and additional achiral alcohols.