These authors contributed equally to this work.
Self-Assembly of DNA Origami and Single-Stranded Tile Structures at Room Temperature†
Article first published online: 10 JUL 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 35, pages 9219–9223, August 26, 2013
How to Cite
Zhang, Z., Song, J., Besenbacher, F., Dong, M. and Gothelf, K. V. (2013), Self-Assembly of DNA Origami and Single-Stranded Tile Structures at Room Temperature . Angew. Chem. Int. Ed., 52: 9219–9223. doi: 10.1002/anie.201303611
We thank William Shih and Yonggang Ke for providing the DNA strands of 24HB, as well as Niels Voigt and Christian Rosen for communication. This research was supported by grants from the Danish National Research Foundation to the Center for DNA Nanotechnology and the Danish Council for Independent Research for an Eliteforsk Award. M.D. acknowledges financial support from the Carlsberg Foundation, and the Villum Foundation.
- Issue published online: 22 AUG 2013
- Article first published online: 10 JUL 2013
- Manuscript Received: 28 APR 2013
- Danish National Research Foundation
- Center for DNA Nanotechnology
- Danish Council for Independent Research
- Carlsberg Foundation
- Villum Foundation
- DNA origami;
- DNA structures;
- room temperature assembly;
- single-stranded tiles
Efficient self-assembly: Self-assembly of DNA nanostructures at room temperature was achieved by incubating the component strands in the presence of a denaturing agent (30–40% formamide). This isothermal method is efficient for assembly of both DNA origami (purple, see scheme) and single-stranded tile (SST, blue) structures, as well as an SST ribbon growing on an origami template.