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The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition

Authors

  • Dr. Faustine Dubar,

    1. Université Lille1, Unité de Catalyse et Chimie du Solide—UMR CNRS 8181, B.P. 90108, 59652 Villeneuve d'Ascq Cedex (France)
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  • Dr. Christian Slomianny,

    1. Université Lille1, Inserm U1003—Laboratoire de Physiologie Cellulaire, Bâtiment SN3, 59655 Villeneuve d'Ascq Cedex (France)
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  • Dr. Jamal Khalife,

    1. CIIL, Inserm U 1019, UMR CNRS 8024 Université Lille Nord de 15 France, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex (France)
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  • Dr. Daniel Dive,

    1. CIIL, Inserm U 1019, UMR CNRS 8024 Université Lille Nord de 15 France, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex (France)
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  • Hadidjatou Kalamou,

    1. CIIL, Inserm U 1019, UMR CNRS 8024 Université Lille Nord de 15 France, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex (France)
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  • Dr. Yann Guérardel,

    1. Université Lille1, Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, IFR 147, 59650 Villeneuve d'Ascq Cedex (France)
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  • Prof. Philippe Grellier,

    1. National Museum of Natural History, UMR 7245 CNRS-MNHN, Team APE, CP 52, 57 Rue Cuvier, Paris 75005 (France)
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  • Prof. Christophe Biot

    Corresponding author
    1. Université Lille1, Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, IFR 147, 59650 Villeneuve d'Ascq Cedex (France)
    • Université Lille1, Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, IFR 147, 59650 Villeneuve d'Ascq Cedex (France)
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  • This study was funded by a grant from the Ministère de l’Enseignement Supérieur to F.D.

Abstract

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Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO. in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.

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