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Copper-Catalyzed Dehydrogenative Coupling of Arenes with Alcohols


  • We thank the DFG (SFB/TRR-88, “3MET”), and the Swiss National Foundation (fellowship to D.K.) for financial support, and Prof. Dr. F. W. Patureau for helpful discussion.


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What a couple! Arenes functionalized with donating groups undergo oxidative dehydrogenative coupling with alcohols in the presence of a copper/silver catalyst system. This intermolecular C[BOND]H alkoxylation provides a convenient synthetic route to the important class of aryl ethers. The catalyst system also allows the alkoxylation of benzylic C[BOND]H groups with formation of benzyl alkyl ethers.