We acknowledge the EPRSC (Leadership Fellowship) and GSK for funding. Mass spectrometry data was acquired at the EPSRC UK National Mass Spectrometry Facility at Swansea University. We are grateful to Dr. Luke Humphreys (GSK) and Dr. Anna Allen for useful discussion and assistance in the preparation of this manuscript.
Copper-Catalyzed Intramolecular Electrophilic Carbofunctionalization of Allylic Amides†
Article first published online: 15 JUL 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 35, pages 9284–9288, August 26, 2013
How to Cite
Cahard, E., Bremeyer, N. and Gaunt, M. J. (2013), Copper-Catalyzed Intramolecular Electrophilic Carbofunctionalization of Allylic Amides . Angew. Chem. Int. Ed., 52: 9284–9288. doi: 10.1002/anie.201303724
- Issue published online: 22 AUG 2013
- Article first published online: 15 JUL 2013
- Manuscript Received: 1 MAY 2013
- diaryliodonium salts;
- homogeneous catalysis;
An endo-selective copper-catalyzed oxyarylation and oxyvinylation of allylic amides was developed. The products are the six-membered ring oxazines and are formed exclusively as the anti isomers. A range of substituted allylic amides and a wide selection of diaryliodonium and vinyl(aryl)iodonium triflates are compatible with this transformation.