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Keywords:

  • asymmetric synthesis;
  • cyclization;
  • domino reactions;
  • Heck reaction;
  • palladium catalysis
Thumbnail image of graphical abstract

Domino cyclization: Alkylpalladium intermediates in an asymmetric Heck reaction were intercepted by a second alkene to give tricyclic products with high enantioselectivity (see scheme; Boc=tert-butoxycarbonyl). The method was applied to the asymmetric synthesis of a precursor of (−)-martinellic acid, a folk eye medicine in South America.