Get access

Chemical Diversification of Sialic Acid Glycosides by Stereospecific, Chemoselective Deamination

Authors


  • We thank the NIH (GM 62160) for support of this work, and Dr. P. K. Kancharla for experimental assistance.

Abstract

original image

Late bloomer: Nitrosation of peracetylated sialic acid glycosides followed by treatment with sodium trifluoroethoxide and then a suitable nucleophile enables the late-stage modification of these glycosides with stereospecific replacement of the acetamido group. This method should enable access to many glycoside derivatives with a minimum of synthetic effort.

Get access to the full text of this article

Ancillary