This work is supported by the European Research Council under the European Community’s Seventh Framework Program (FP7 2007–2013)/ERC Grant agreement no 257891. We thank Dr. R. Scopelliti for X-ray crystallographic analysis of 2 l.
Enantioselective CH Arylation Strategy for Functionalized Dibenzazepinones with Quaternary Stereocenters†
Article first published online: 19 JUN 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 30, pages 7865–7868, July 22, 2013
How to Cite
Saget, T. and Cramer, N. (2013), Enantioselective CH Arylation Strategy for Functionalized Dibenzazepinones with Quaternary Stereocenters . Angew. Chem. Int. Ed., 52: 7865–7868. doi: 10.1002/anie.201303816
- Issue published online: 17 JUL 2013
- Article first published online: 19 JUN 2013
- Manuscript Received: 3 MAY 2013
- European Research Council. Grant Number: 257891
- asymmetric catalysis;
- CH activation;
- cooperative effects;
Tada! Highly functionalized chiral dibenzazepinones are obtained by a mild palladium(0)-catalyzed enantioselective CH arylation with excellent selectivities by using simple taddol phosphoramidite ligands. The amide tether allows exclusive regioselectivity through a rare eight-membered palladacycle intermediate.