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Keywords:

  • asymmetric catalysis;
  • C[BOND]H activation;
  • cooperative effects;
  • heterocycle;
  • palladium
Thumbnail image of graphical abstract

Tada! Highly functionalized chiral dibenzazepinones are obtained by a mild palladium(0)-catalyzed enantioselective C[BOND]H arylation with excellent selectivities by using simple taddol phosphoramidite ligands. The amide tether allows exclusive regioselectivity through a rare eight-membered palladacycle intermediate.