Enantioselective C[BOND]H Arylation Strategy for Functionalized Dibenzazepinones with Quaternary Stereocenters

Authors


  • This work is supported by the European Research Council under the European Community’s Seventh Framework Program (FP7 2007–2013)/ERC Grant agreement no 257891. We thank Dr. R. Scopelliti for X-ray crystallographic analysis of 2 l.

Abstract

original image

Tada! Highly functionalized chiral dibenzazepinones are obtained by a mild palladium(0)-catalyzed enantioselective C[BOND]H arylation with excellent selectivities by using simple taddol phosphoramidite ligands. The amide tether allows exclusive regioselectivity through a rare eight-membered palladacycle intermediate.

Ancillary