Get access

Convergent Chemical Synthesis of Histone H2B Protein for the Site-Specific Ubiquitination at Lys34


  • This work was supported by the Israel Science Foundation (A.B.) and the Max Planck Society (W.F.). P.S. gratefully acknowledges the Israel Ministry of Science and Technology for financial support.


original image

As You Like It: The convergent chemical synthesis of the histone H2B protein was achieved. This approach enabled the attachment of ubiquitin at Lys34 (see picture) and should make it possible to synthesize H2B with any other posttranslational modification in demand.