Domino Catalysis: Palladium-Catalyzed Carbonylation of Allylic Alcohols to β,γ-Unsaturated Esters


  • The research has been funded by the State of Mecklenburg-Western Pomerania, the BMBF, and the DFG (Leibniz Prize). We thank Dr. W. Baumann, Dr. C. Fischer, S. Buchholz, S. Schareina, A. Koch, and S. Rossmeisl (all at LIKAT) for their excellent technical and analytical support. Q.L. thanks the Alexander von Humboldt Foundation for financial support.


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Make it green: The Pd-catalyzed carbonylation of allylic alcohols with aliphatic alcohols represents a cost-effective, salt-free, and atom-economic carbonylation process generating water as the sole by-product. Mechanistic studies uncovered a new domino C[BOND]O coupling/carbonylation reaction pathway.