Catalyst-Controlled Highly Selective Coupling and Oxygenation of Olefins: A Direct Approach to Alcohols, Ketones, and Diketones

Authors

  • Yijin Su,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
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    • These authors contributed equally to this work.

  • Xiang Sun,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
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    • These authors contributed equally to this work.

  • Guolin Wu,

    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
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  • Dr. Ning Jiao

    Corresponding author
    1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
    2. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, Shanghai 200062 (China)
    • State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China)
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  • Financial support from the National Basic Research Program of China (973 Program 2009CB825300), the National Science Foundation of China (21172006), and Peking University is greatly appreciated. We thank Zejun Xu for reproducing the results for 3 j, 4 i, and 5 e.

Abstract

original image

Oxygen? That's radical! A method for the direct synthesis of substituted alcohols, ketones, and diketones through a catalyst-controlled highly chemoselective coupling and oxygenation of olefins has been developed. The method is simple and practical, can be switched by the selection of different catalysts, and employs molecular oxygen as both an oxidant and a reagent.

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