This research was supported by the Daiichi Sankyo Co., Ltd.
Palladium-Catalyzed Reductive Carbonylation of Aryl Halides with N-Formylsaccharin as a CO Source†
Article first published online: 3 JUL 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 33, pages 8611–8615, August 12, 2013
How to Cite
Ueda, T., Konishi, H. and Manabe, K. (2013), Palladium-Catalyzed Reductive Carbonylation of Aryl Halides with N-Formylsaccharin as a CO Source . Angew. Chem. Int. Ed., 52: 8611–8615. doi: 10.1002/anie.201303926
- Issue published online: 8 AUG 2013
- Article first published online: 3 JUL 2013
- Manuscript Received: 8 MAY 2013
- synthetic methods
Easy peasy: The title reaction employs N-formylsaccharin, which is an easily accessible crystalline compound, as an effective CO source. The reactions proceed with a small excess of the CO source at moderate temperatures and were successfully applied to a wide range of aryl bromides. DMF=N,N-dimethylformamide, dppb=1,4-bis-(diphenylphosphino)butane.