Diversity-Oriented Three-Component Reactions of Diazo Compounds with Anilines and 4-Oxo-Enoates

Authors

  • Changcheng Jing,

    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)
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  • Dr. Dong Xing,

    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)
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  • Yu Qian,

    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)
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  • Taoda Shi,

    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)
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  • Yun Zhao,

    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)
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  • Prof. Dr. Wenhao Hu

    Corresponding author
    1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)
    • Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663, North Zhongshan Road, Shanghai, 200062 (China)

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  • We are grateful for financial support from the NSF of China (20932003 and 21125209), the MOST of China (2011CB808600), and STCSM (12JC1403800).

Abstract

original image

Choosing a path: The title reaction can proceed through two different reaction pathways, and is controlled by the addition sequence of the substrates. Divergent polyfunctional products, pyrrolidines or linear α-amino ester derivatives, are obtained in good yields and high diastereoselectivities.

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