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Keywords:

  • copper;
  • enantioselective conjugate additions;
  • N-heterocyclic carbenes;
  • organoaluminums;
  • quaternary carbons
Thumbnail image of graphical abstract

Acyclic quaternary carbons by conjugate addition: The first examples of catalytic enantioselective conjugate additions of aryl and alkyl units that generate acyclic all-carbon quaternary stereogenic centers have been developed (see scheme). The requisite organoaluminum reagents can either be prepared in situ from easily available organolithiums or purchased at low cost.