Iridium-Catalyzed, Diastereoselective Dehydrogenative Silylation of Terminal Alkenes with (TMSO)2MeSiH


  • We thank the NSF (CHE-1213409) for financial support and Johnson Matthey for a gift of [{Ir(cod)OMe}2]. We thank Leslie Bienen of C3 Science for assistance in manuscript preparation. TMS=trimethylsilyl.


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Ligands' choice: The title reaction was achieved under mild conditions with low catalyst loading. The diastereoselectivity of the reaction can be controlled by choosing the appropriate ancillary ligand (see scheme; coe=cyclooctene). The silylation products undergo further transformation such as oxidation or cross-coupling.