Phosphoramidate Tantalum Complexes for Room-Temperature C[BOND]H Functionalization: Hydroaminoalkylation Catalysis


  • We thank Jacky C.-H. Yim for assistance with X-ray crystallography and Boehringer Ingelheim (Canada) Ltd. and NSERC for financial support of this work. This research was funded by the Canada Research Chairs program.


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A cooled reaction: Phosphoramidate–ClTaMe3 complexes promote the first example of room-temperature hydroaminoalkylation catalysis. This reaction can be realized under solvent-free conditions and with challenging substrates such as styrenes and dialkyl amines. When using a vinylsilane substrate, for the first time the linear regioisomer is obtained preferentially using a Group 5 metal. TBS=tert-butyldimethylsilyl, TMS=trimethylsilyl.