• Open Access

Palladium- and Ruthenium-Catalyzed Cycloisomerization of Enynamides and Enynhydrazides: A Rapid Approach to Diverse Azacyclic Frameworks

Authors


  • We thank the EPSRC for an Advanced Research Fellowship (E.A.A.; EP/E055273/1) and for further funding (C.D.C.; EP/H025839/1). We also thank AstraZeneca for a CASE award (P.R.W.).

Abstract

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I want to ride my azacycle: The title reaction of enynamides affords a wide diversity of azacycles. The reactions are high-yielding, highly stereoselective, and proceed rapidly under mild reaction conditions. Equivalent transformations using enynhydrazides offer new routes to pyrazole and indazole scaffolds. Boc=tert-butoxycarbonyl, EWG=electron-withdrawing group, Ns=4-nitrobenzenesulfonyl, Ts=4-toluenesulfonyl.

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