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Keywords:

  • drug screening;
  • histidine tags;
  • PEGylation;
  • protein design;
  • protein modifications
Thumbnail image of graphical abstract

Increasing the half-life of therapeutic proteins in a specific, fast, and reliable way could greatly benefit the discovery of novel protein drugs. In their Communication on page 6880 ff., K. C. Lee, S. Lee, and co-workers conjugate Ni-NTA to poly(ethylene glycol) and then label oligohistidine-tagged therapeutic proteins to improve their stability in vivo without compromising bioactivity.