Back Cover: Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo (Angew. Chem. Int. Ed. 27/2013)

Authors

  • Dr. Tae Hyung Kim,

    1. Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University, 400 North Broadway, Baltimore, MD 21231 (USA)
    2. College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-gu, Suwon 440-746 (Korea)
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  • Dr. Magdalena Swierczewska,

    1. Institute for NanoBioTechnology, Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Johns Hopkins University (USA)
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  • Dr. Yumin Oh,

    1. Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University, 400 North Broadway, Baltimore, MD 21231 (USA)
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  • Dr. AeRyon Kim,

    1. Department of Pathology, Johns Hopkins University (USA)
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  • Prof. Dr. Dong Gyu Jo,

    1. College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-gu, Suwon 440-746 (Korea)
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  • Prof. Dr. Jae Hyung Park,

    1. Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon (Korea)
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  • Prof. Dr. Youngro Byun,

    1. College of Pharmacy, Seoul National University, Seoul (Korea)
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  • Prof. Dr. Scheherazade Sadegh-Nasseri,

    1. Department of Pathology, Johns Hopkins University (USA)
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  • Prof. Dr. Martin G. Pomper,

    1. Institute for NanoBioTechnology, Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Johns Hopkins University (USA)
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  • Prof. Dr. Kang Choon Lee,

    Corresponding author
    1. College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-gu, Suwon 440-746 (Korea)
    • Kang Choon Lee, College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-gu, Suwon 440-746 (Korea)

      Seulki Lee, Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University, 400 North Broadway, Baltimore, MD 21231 (USA)

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  • Prof. Dr. Seulki Lee

    Corresponding author
    1. Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University, 400 North Broadway, Baltimore, MD 21231 (USA)
    • Kang Choon Lee, College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-gu, Suwon 440-746 (Korea)

      Seulki Lee, Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University, 400 North Broadway, Baltimore, MD 21231 (USA)

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Abstract

original image

Increasing the half-life of therapeutic proteins in a specific, fast, and reliable way could greatly benefit the discovery of novel protein drugs. In their Communication on page 6880 ff., K. C. Lee, S. Lee, and co-workers conjugate Ni-NTA to poly(ethylene glycol) and then label oligohistidine-tagged therapeutic proteins to improve their stability in vivo without compromising bioactivity.

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