Cover Picture: Organocatalysis by Neutral Multidentate Halogen-Bond Donors (Angew. Chem. Int. Ed. 27/2013)



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Neutral multidentate halogen-bond donors (halogen-based Lewis acids) can be used as organocatalysts in a halide abstraction reaction. In their Communication on page 7028 ff., S. M. Huber et al. describe the halogen-bond-catalyzed reaction of 1-chloroisochroman with ketene silyl acetals. The organocatalytic activity crucially depends on the iodine substituents of the halogen-bond donors, and hidden acid catalysts can be ruled out with high probability.