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The Cross-Dehydrogenative Coupling of Cmath formula[BOND]H Bonds: A Versatile Strategy for C[BOND]C Bond Formations

Authors

  • Simon A. Girard,

    1. Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montréal, Quebec H3A 0B8 (Canada) http://cjli.mcgill.ca
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    • These authors contributed equally to this work.

  • Dr. Thomas Knauber,

    1. Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montréal, Quebec H3A 0B8 (Canada) http://cjli.mcgill.ca
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    • These authors contributed equally to this work.

  • Prof. Dr. Chao-Jun Li

    Corresponding author
    1. Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montréal, Quebec H3A 0B8 (Canada) http://cjli.mcgill.ca
    • Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montréal, Quebec H3A 0B8 (Canada) http://cjli.mcgill.ca

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Abstract

Over the last decade, substantial research has led to the introduction of an impressive number of efficient procedures which allow the selective construction of C[BOND]C bonds by directly connecting two different C[BOND]H bonds under oxidative conditions. Common to these methodologies is the generation of the reactive intermediates in situ by activation of both C[BOND]H bonds. This strategy was introduced by the group of Li as cross-dehydrogenative coupling (CDC) and discloses waste-minimized synthetic alternatives to classic coupling procedures which rely on the use of prefunctionalized starting materials. This Review highlights the recent progress in the field of cross-dehydrogenative Cmath formula[BOND]C formations and provides a comprehensive overview on existing procedures and employed methodologies.

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