This work was supported by a Grant-in-Aid for Scientific Research (No. 25E07B212 and 23005914) from the Ministry of Education, Culture, Sports, Science and Technology (Japan).
Asymmetric Hydrogenation of tert-Alkyl Ketones: DMSO Effect in Unification of Stereoisomeric Ruthenium Complexes†
Article first published online: 10 JUL 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 35, pages 9313–9315, August 26, 2013
How to Cite
Yamamura, T., Nakatsuka, H., Tanaka, S. and Kitamura, M. (2013), Asymmetric Hydrogenation of tert-Alkyl Ketones: DMSO Effect in Unification of Stereoisomeric Ruthenium Complexes . Angew. Chem. Int. Ed., 52: 9313–9315. doi: 10.1002/anie.201304408
- Issue published online: 22 AUG 2013
- Article first published online: 10 JUL 2013
- Manuscript Received: 22 MAY 2013
- Grant-in-Aid for Scientific Research. Grant Numbers: 25E07B212, 23005914
- Ministry of Education, Culture, Sports, Science and Technology (Japan)
- ligand design;
- synthetic methods
Face off: The ruthenium complexes of a new axially chiral PNN ligand (L) are highly efficient in the presence of dimethylsulfoxide (DMSO) for hydrogenation of both functionalized and unfunctionalized tert-alkyl ketones. DMSO is thought to narrow down the many possible complex stereoisomers into a single facial L/Ru complex, thus enhancing the reactivity, selectivity, and productivity.