Asymmetric Hydrogenation of tert-Alkyl Ketones: DMSO Effect in Unification of Stereoisomeric Ruthenium Complexes

Authors

  • Tomoya Yamamura,

    1. Graduate School of Pharmaceutical Sciences, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8601 (Japan)
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  • Hiroshi Nakatsuka,

    1. Graduate School of Pharmaceutical Sciences, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8601 (Japan)
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  • Shinji Tanaka,

    1. Research Center for Materials Science, Nagoya University (Japan)
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  • Prof. Dr. Masato Kitamura

    Corresponding author
    1. Graduate School of Pharmaceutical Sciences, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8601 (Japan)
    2. Research Center for Materials Science, Nagoya University (Japan)
    • Graduate School of Pharmaceutical Sciences, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8601 (Japan)

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  • This work was supported by a Grant-in-Aid for Scientific Research (No. 25E07B212 and 23005914) from the Ministry of Education, Culture, Sports, Science and Technology (Japan).

Abstract

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Face off: The ruthenium complexes of a new axially chiral PNN ligand (L) are highly efficient in the presence of dimethylsulfoxide (DMSO) for hydrogenation of both functionalized and unfunctionalized tert-alkyl ketones. DMSO is thought to narrow down the many possible complex stereoisomers into a single facial L/Ru complex, thus enhancing the reactivity, selectivity, and productivity.

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