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Keywords:

  • azaborines;
  • biphenyl;
  • boron;
  • heterocycles;
  • isosterism
Thumbnail image of graphical abstract

A Sn-phony in B! BN isosteres of biphenyl compounds are prepared through Rh-catalyzed cross-coupling between 2-chloro-1,2-azaborines and arylstannanes (see scheme). The synthetic method should enable investigations of structure–activity relationships (SARs) by expanding the chemical space of the pharmaceutically relevant biphenyl structure through BN/CC isosterism.