Correspondence concerning X-ray crystallography should be directed to Lev Zakharov (email@example.com). This research was supported by the National Institutes of Health (National Institute of General Medical Sciences, R01-GM094541 and R41-GM099181). Funding for the University of Oregon Chemistry Research and Instrumentation Services has been provided in part by the NSF (CHE-0923589). We thank Dr. Adam Marwitz for performing the stability assessment of BN felbinac.
Rhodium-Catalyzed Boron Arylation of 1,2-Azaborines†
Article first published online: 5 JUL 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 35, pages 9316–9319, August 26, 2013
How to Cite
Rudebusch, G. E., Zakharov, L. N. and Liu, S.-Y. (2013), Rhodium-Catalyzed Boron Arylation of 1,2-Azaborines . Angew. Chem. Int. Ed., 52: 9316–9319. doi: 10.1002/anie.201304443
- Issue published online: 22 AUG 2013
- Article first published online: 5 JUL 2013
- Manuscript Received: 23 MAY 2013
- National Institutes of Health. Grant Numbers: R01-GM094541, R41-GM099181
- NSF. Grant Number: CHE-0923589
A Sn-phony in B! BN isosteres of biphenyl compounds are prepared through Rh-catalyzed cross-coupling between 2-chloro-1,2-azaborines and arylstannanes (see scheme). The synthetic method should enable investigations of structure–activity relationships (SARs) by expanding the chemical space of the pharmaceutically relevant biphenyl structure through BN/CC isosterism.