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Rhodium-Catalyzed Oxidative Annulation of Sulfoximines and Alkynes as an Approach to 1,2-Benzothiazines


  • W.D. and F.P. thank the China Scholarship Council for predoctoral stipends. K.P. acknowledges support by the Alexander von Humboldt Foundation. We also thank Prof. Dr. J. Cheng (Changzhou University) for helpful discussions and Prof. Dr. U. Englert as well as Dr. R. Wang (both RWTH Aachen University) for the collection of X-ray crystallographic data.


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Revitalization by oxygen: A rhodium(III)-catalyzed oxidative C[BOND]H/N[BOND]H activation/annulation sequence provided access to a variety of substituted 1,2-benzothiazine derivatives from readily available NH-sulfoximines and alkynes (see scheme; Cp*=C5Me5). The oxidation system consisted of molecular oxygen in combination with a catalytic amount of Fe(OAc)2.

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