Gold-Catalyzed Tandem Cycloisomerization/Cope Rearrangement: An Efficient Access to the Hydroazulenic Motif

Authors


  • We are deeply appreciative of financial support from the Ecole Polytechnique to Z.C. and thank Rhodia Chimie Fine (Dr. F. Metz) for a generous gift of HNTf2.

Abstract

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Simply complex: The title reaction proceeds at a low loading of catalyst (1 mol %) and allows an efficient and stereoselective access to the hydroazulenic motif, which is found in numerous natural products having significant biological activities. Tf=trifluoromethanesulfonyl, XPhos=2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl.

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