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Highly Efficient, Water-Soluble Polarizing Agents for Dynamic Nuclear Polarization at High Frequency


  • The research reported herein is based upon work supported by Aix-Marseille Université, CNRS and Bruker BioSpin. P. Tordo and O. Ouari thank Prof. L. Emsley (ENS Lyon), Prof. Copéret (ETH Zurich) and their co-workers for valuable discussions. We also thank Dr. W. Maas (Bruker BioSpin) for his continued support and interest towards the development of novel polarizing agents.


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Well polarized: Two new polarizing agents PyPol and AMUPol soluble in glycerol/water mixtures are used for dynamic nuclear polarization (DNP) NMR spectroscopy. The enhancement factors (ε) are about 3.5 to 4 times larger than for the established agent TOTAPOL at 263 and 395 GHz. For AMUPol, the temperature dependence of ε allows DNP experiments to be performed at temperatures significantly higher than for typical high-field DNP NMR experiments.