These authors contributed equally to this work.
Total Synthesis and Structural Revision of Viridicatumtoxin B†
Article first published online: 24 JUL 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 33, pages 8736–8741, August 12, 2013
How to Cite
Nicolaou, K. C., Nilewski, C., Hale, C. R. H., Ioannidou, H. A., ElMarrouni, A. and Koch, L. G. (2013), Total Synthesis and Structural Revision of Viridicatumtoxin B . Angew. Chem. Int. Ed., 52: 8736–8741. doi: 10.1002/anie.201304691
Financial support was provided by the National Institutes of Health (USA) (grant AI055475-11) and the Skaggs Institute of Research. Fellowships to C.N. (Feodor Lynen Research Fellowship, Alexander von Humboldt Foundation), C.R.H.H. (NSF Graduate Research Fellowship), and A.E. (Fundación Alfonso Martín Escudero) are gratefully appreciated. We thank Dr. R. K. Chadha for X-ray crystallographic assistance and Dr. D. H. Huang and Dr. L. Pasternack for NMR spectroscopic assistance. We thank Prof. W.-G. Kim for graciously providing scanned NMR spectra of natural viridicatumtoxin B.
- Issue published online: 8 AUG 2013
- Article first published online: 24 JUL 2013
- Manuscript Received: 30 MAY 2013
- National Institutes of Health. Grant Number: AI055475-11
- Skaggs Institute of Research
- natural products;
- structural revision;
- total synthesis
Will the real viridicatumtoxin B please stand up: The total synthesis of viridicatumtoxin B resulted in its structural revision and opens the way for analogue construction and biological evaluation of this complex tetracycline-like antibiotic. The highly convergent strategy employed allows for swift construction of the entire carbocyclic framework of the molecule.