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Keywords:

  • asymmetric synthesis;
  • cyclization;
  • fluorine;
  • helical structures;
  • synthetic methods
Thumbnail image of graphical abstract

Twist of ‘F'ate: Various helical-shaped fluorinated tetracyclic molecules were prepared by fluorocarbocyclization of prochiral alkenes. The development of a new class of chiral Selectfluor (1) proved instrumental in developing an asymmetric variant of this transformation. These novel chiral N-F reagents are readily accessible by fluorine transfer from shelf-stable N-fluoropyridinium salts.