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Keywords:

  • antibiotics;
  • biosynthesis;
  • elimination;
  • lantipeptides;
  • polyketides
Thumbnail image of graphical abstract

Enoyl intermediates are normally obtained through β-elimination of β-hydroxy carbonyl compounds. The OH group is eliminated either directly or is first activated through phosphorylation. Alternative strategies have now been identified: Glutamination or acetylation of a β-hydroxycarbonyl compound followed by β-elimination of an ester was proven to be a key step in the biosynthesis of class I lantipeptide and tetronate antibiotics.