H.S.O. acknowledges the Alexander von Humboldt Foundation for a Friedrich Wilhelm Bessel Research Award. This work was supported by the cluster of excellence UniCat (granted by the German research council-DFG).
Elimination Reactions of Esters in the Biosynthesis of Polyketides and Ribosomal Peptides†
Article first published online: 9 AUG 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 35, pages 9082–9084, August 26, 2013
How to Cite
Krawczyk, B., van Herwerden, E. F., Overkleeft, H. S. and Süssmuth, R. D. (2013), Elimination Reactions of Esters in the Biosynthesis of Polyketides and Ribosomal Peptides . Angew. Chem. Int. Ed., 52: 9082–9084. doi: 10.1002/anie.201304851
- Issue published online: 22 AUG 2013
- Article first published online: 9 AUG 2013
- Manuscript Received: 5 JUN 2013
- German research council
Enoyl intermediates are normally obtained through β-elimination of β-hydroxy carbonyl compounds. The OH group is eliminated either directly or is first activated through phosphorylation. Alternative strategies have now been identified: Glutamination or acetylation of a β-hydroxycarbonyl compound followed by β-elimination of an ester was proven to be a key step in the biosynthesis of class I lantipeptide and tetronate antibiotics.