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Keywords:

  • aldehydes;
  • allylic alcohols;
  • asymmetric catalysis;
  • isomerization;
  • ruthenium
Thumbnail image of graphical abstract

Enantioselective isomerization of γ-substituted primary allylic alcohols into the β-substituted aldehydes with the [RuCl2{(S)-tol-binap}{(R)-dbapen}]/KOH catalyst system is described by T. Ohkuma and co-workers in their Communication on page 7500 ff. A series of E- and Z-configured aromatic and aliphatic allylic alcohols, including a simple primary-alkyl-substituted compound (E)-3-methyl-2-hepten-1-ol, is transformed to the aldehydes in almost enantiomerically pure form.