Inside Cover: Enantioselective Isomerization of Primary Allylic Alcohols into Chiral Aldehydes with the tol-binap/dbapen/Ruthenium(II) Catalyst (Angew. Chem. Int. Ed. 29/2013)

Authors

  • Prof. Dr. Noriyoshi Arai,

    1. Division of Chemical Process Engineering and Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628 (Japan)
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  • Keisuke Sato,

    1. Division of Chemical Process Engineering and Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628 (Japan)
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  • Keita Azuma,

    1. Division of Chemical Process Engineering and Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628 (Japan)
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  • Prof. Dr. Takeshi Ohkuma

    Corresponding author
    1. Division of Chemical Process Engineering and Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628 (Japan)
    • Division of Chemical Process Engineering and Frontier Chemistry Center, Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628 (Japan)
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Abstract

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Enantioselective isomerization of γ-substituted primary allylic alcohols into the β-substituted aldehydes with the [RuCl2{(S)-tol-binap}{(R)-dbapen}]/KOH catalyst system is described by T. Ohkuma and co-workers in their Communication on page 7500 ff. A series of E- and Z-configured aromatic and aliphatic allylic alcohols, including a simple primary-alkyl-substituted compound (E)-3-methyl-2-hepten-1-ol, is transformed to the aldehydes in almost enantiomerically pure form.

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