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Keywords:

  • allenes;
  • asymmetric catalysis;
  • C[BOND]H activation;
  • DYKAT;
  • rhodium
Thumbnail image of graphical abstract

Racemization required: Rhodium(I)-catalyzed C[BOND]H activation directed by unprotected ketimines initiates selective [3+2] cycloaddition with allenes, providing access to highly substituted indenylamines. The reaction proceeds through the dynamic kinetic asymmetric transformation of racemic allenes. The catalyst controls the enantio- and diastereoselectivity, the regioselectivities of the C[BOND]H activation and allene incorporation, as well as the E/Z ratio.