Inside Cover: A Chemo-Enzymatic Approach for Site-Specific Modification of the RNA Cap (Angew. Chem. Int. Ed. 30/2013)

Authors

  • Daniela Schulz,

    1. Universität Hamburg, Department Chemie, Institut für Biochemie und Molekularbiologie, Martin-Luther-King Platz 6, 20146 Hamburg (Germany)
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  • Josephin Marie Holstein,

    1. Universität Hamburg, Department Chemie, Institut für Biochemie und Molekularbiologie, Martin-Luther-King Platz 6, 20146 Hamburg (Germany)
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  • Dr. Andrea Rentmeister

    Corresponding author
    1. Universität Hamburg, Department Chemie, Institut für Biochemie und Molekularbiologie, Martin-Luther-King Platz 6, 20146 Hamburg (Germany)
    • Universität Hamburg, Department Chemie, Institut für Biochemie und Molekularbiologie, Martin-Luther-King Platz 6, 20146 Hamburg (Germany)
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Abstract

original image

Targeting the mRNA cap by a chemo-enzymatic approach opens up new possibilities in mRNA isolation and visualization. In their Communication on page 7874 ff. A. Rentmeister and co-workers present a novel two-step approach for the regiospecific labeling of the m7G cap, a hallmark of eukaryotic mRNAs. They make use of a trimethylguanosine variant capable of transferring reactive groups from AdoMet analogues to the cap. The transferred residues are amenable to click reactions.

Cartoon 1.

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