Targeting the mRNA cap by a chemo-enzymatic approach opens up new possibilities in mRNA isolation and visualization. In their Communication on page 7874 ff. A. Rentmeister and co-workers present a novel two-step approach for the regiospecific labeling of the m7G cap, a hallmark of eukaryotic mRNAs. They make use of a trimethylguanosine variant capable of transferring reactive groups from AdoMet analogues to the cap. The transferred residues are amenable to click reactions.
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